{"id":7294,"date":"2018-02-23T12:12:05","date_gmt":"2018-02-23T20:12:05","guid":{"rendered":"https:\/\/www.sfj-pharma.com\/?p=7294"},"modified":"2021-05-13T14:30:10","modified_gmt":"2021-05-13T22:30:10","slug":"dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis","status":"publish","type":"post","link":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/","title":{"rendered":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis"},"content":{"rendered":"<p><b>Background:<\/b>In the ongoing phase 3 ARCHER 1050 study, first-line treatment with daco significantly improved the primary endpoint of progression-free survival, duration of response, and time to treatment failure vs gef in patients (pts) with epidermal growth factor receptor (<i>EGFR<\/i>) mutation-positive advanced non-small cell lung cancer (NSCLC) (Wu et al, <i>Lancet Oncol<\/i>, 2017). Here, we present the OS results.<\/p>\n<p><b>Methods:<\/b>Pts with newly diagnosed stage IIIB\/IV or recurrent NSCLC harboring an <i>EGFR<\/i> mutation (exon 19 del or exon 21 L858R \u00b1 exon 20 T790M) and without central nervous system metastasis were randomized 1:1 to oral daco 45 mg\/day or oral gef 250 mg\/day. Pts were stratified by race and <i>EGFR<\/i> mutation type.<\/p>\n<p><b>Results:<\/b>As of 17 February 2017, a total of 220 deaths (48.7%) occurred over a median follow-up of 31.3 months (mo): 103 (45.4%) in the daco arm (n = 227) and 117 (52.0%) in the gef arm (n = 225). Daco showed a significant improvement in OS compared to gef (hazard ratio [HR], 0.76; 95% confidence interval [CI], 0.582\u20130.993; 2-sided <i>P<\/i>= 0.044 based on stratified analysis). Median OS (95% CI) was 34.1 mo (29.5\u201337.7) with daco vs 26.8 mo (23.7\u201332.1) with gef. Survival rates at 30 mo were 56.2% with daco and 46.3% with gef. The table shows preliminary OS subgroup analyses by race and <i>EGFR<\/i> mutation type, with &gt;55% of pts being censored in some subsets. OS subgroup analyses were consistent with the primary OS analysis across most baseline characteristics.<\/p>\n<p><b>Conclusions:<\/b>In pts with advanced <i>EGFR<\/i> mutation-positive NSCLC, daco is the first to show a significant improvement in OS in a phase 3 trial compared with a standard-of-care tyrosine kinase inhibitor. Daco should be considered as one of the standard treatment options for these pts. Clinical trial information: <a href=\"http:\/\/clinicaltrials.gov\/show\/NCT01774721\">NCT01774721<\/a><\/p>\n<p><a href=\"https:\/\/meetinglibrary.asco.org\/record\/161487\/abstract\" target=\"_blank\" rel=\"noopener noreferrer\">View full article on ASCO Meeting Library.<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background:In the ongoing phase 3 ARCHER 1050 study, first-line treatment with daco significantly improved the primary endpoint of progression-free survival, duration of response, and time to treatment failure vs gef in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer&#8230;<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals\" \/>\n<meta property=\"og:description\" content=\"Background:In the ongoing phase 3 ARCHER 1050 study, first-line treatment with daco significantly improved the primary endpoint of progression-free survival, duration of response, and time to treatment failure vs gef in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\" \/>\n<meta property=\"og:site_name\" content=\"SFJ Pharmaceuticals\" \/>\n<meta property=\"article:published_time\" content=\"2018-02-23T20:12:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2021-05-13T22:30:10+00:00\" \/>\n<meta name=\"author\" content=\"Lily Xu\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Lily Xu\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\"},\"author\":{\"name\":\"Lily Xu\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/770e5cbce35f5f0f90d2218806ceba11\"},\"headline\":\"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis\",\"datePublished\":\"2018-02-23T20:12:05+00:00\",\"dateModified\":\"2021-05-13T22:30:10+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\"},\"wordCount\":285,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/#organization\"},\"articleSection\":[\"Scientific Publications\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\",\"url\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\",\"name\":\"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals\",\"isPartOf\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/#website\"},\"datePublished\":\"2018-02-23T20:12:05+00:00\",\"dateModified\":\"2021-05-13T22:30:10+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.sfj-pharma.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#website\",\"url\":\"https:\/\/www.sfj-pharma.com\/\",\"name\":\"SFJ Pharmaceuticals\",\"description\":\"Resources for Accelerated Clinical Development\",\"publisher\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.sfj-pharma.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#organization\",\"name\":\"SFJ Pharmaceuticals\",\"url\":\"https:\/\/www.sfj-pharma.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/secureservercdn.net\/198.71.233.213\/c59.835.myftpupload.com\/wp-content\/uploads\/2020\/12\/SFJ-Logo-Final-RGB.png?time=1666279552\",\"contentUrl\":\"https:\/\/secureservercdn.net\/198.71.233.213\/c59.835.myftpupload.com\/wp-content\/uploads\/2020\/12\/SFJ-Logo-Final-RGB.png?time=1666279552\",\"width\":750,\"height\":205,\"caption\":\"SFJ Pharmaceuticals\"},\"image\":{\"@id\":\"https:\/\/www.sfj-pharma.com\/#\/schema\/logo\/image\/\"}},{\"@type\":\"Person\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/770e5cbce35f5f0f90d2218806ceba11\",\"name\":\"Lily Xu\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/2b733936c0f668be1f942765f61e3056?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/2b733936c0f668be1f942765f61e3056?s=96&d=mm&r=g\",\"caption\":\"Lily Xu\"},\"url\":\"https:\/\/www.sfj-pharma.com\/author\/lily\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/","og_locale":"en_US","og_type":"article","og_title":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals","og_description":"Background:In the ongoing phase 3 ARCHER 1050 study, first-line treatment with daco significantly improved the primary endpoint of progression-free survival, duration of response, and time to treatment failure vs gef in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer...","og_url":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/","og_site_name":"SFJ Pharmaceuticals","article_published_time":"2018-02-23T20:12:05+00:00","article_modified_time":"2021-05-13T22:30:10+00:00","author":"Lily Xu","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Lily Xu","Est. reading time":"1 minute"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#article","isPartOf":{"@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/"},"author":{"name":"Lily Xu","@id":"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/770e5cbce35f5f0f90d2218806ceba11"},"headline":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis","datePublished":"2018-02-23T20:12:05+00:00","dateModified":"2021-05-13T22:30:10+00:00","mainEntityOfPage":{"@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/"},"wordCount":285,"commentCount":0,"publisher":{"@id":"https:\/\/www.sfj-pharma.com\/#organization"},"articleSection":["Scientific Publications"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#respond"]}]},{"@type":"WebPage","@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/","url":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/","name":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis - SFJ Pharmaceuticals","isPartOf":{"@id":"https:\/\/www.sfj-pharma.com\/#website"},"datePublished":"2018-02-23T20:12:05+00:00","dateModified":"2021-05-13T22:30:10+00:00","breadcrumb":{"@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/www.sfj-pharma.com\/dacomitinib-daco-versus-gefitinib-gef-for-first-line-treatment-of-advanced-nsclc-archer-1050-final-overall-survival-os-analysis\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.sfj-pharma.com\/"},{"@type":"ListItem","position":2,"name":"Dacomitinib (daco) versus gefitinib (gef) for first-line treatment of advanced NSCLC (ARCHER 1050): Final overall survival (OS) analysis"}]},{"@type":"WebSite","@id":"https:\/\/www.sfj-pharma.com\/#website","url":"https:\/\/www.sfj-pharma.com\/","name":"SFJ Pharmaceuticals","description":"Resources for Accelerated Clinical Development","publisher":{"@id":"https:\/\/www.sfj-pharma.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.sfj-pharma.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.sfj-pharma.com\/#organization","name":"SFJ Pharmaceuticals","url":"https:\/\/www.sfj-pharma.com\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.sfj-pharma.com\/#\/schema\/logo\/image\/","url":"https:\/\/secureservercdn.net\/198.71.233.213\/c59.835.myftpupload.com\/wp-content\/uploads\/2020\/12\/SFJ-Logo-Final-RGB.png?time=1666279552","contentUrl":"https:\/\/secureservercdn.net\/198.71.233.213\/c59.835.myftpupload.com\/wp-content\/uploads\/2020\/12\/SFJ-Logo-Final-RGB.png?time=1666279552","width":750,"height":205,"caption":"SFJ Pharmaceuticals"},"image":{"@id":"https:\/\/www.sfj-pharma.com\/#\/schema\/logo\/image\/"}},{"@type":"Person","@id":"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/770e5cbce35f5f0f90d2218806ceba11","name":"Lily Xu","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.sfj-pharma.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/2b733936c0f668be1f942765f61e3056?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/2b733936c0f668be1f942765f61e3056?s=96&d=mm&r=g","caption":"Lily Xu"},"url":"https:\/\/www.sfj-pharma.com\/author\/lily\/"}]}},"rttpg_featured_image_url":null,"rttpg_author":{"display_name":"Lily Xu","author_link":"https:\/\/www.sfj-pharma.com\/author\/lily\/"},"rttpg_comment":0,"rttpg_category":"<a href=\"https:\/\/www.sfj-pharma.com\/category\/scientific-publications\/\" rel=\"category tag\">Scientific Publications<\/a>","rttpg_excerpt":"Background:In the ongoing phase 3 ARCHER 1050 study, first-line treatment with daco significantly improved the primary endpoint of progression-free survival, duration of response, and time to treatment failure vs gef in patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive advanced non-small cell lung cancer...","_links":{"self":[{"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/posts\/7294"}],"collection":[{"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/comments?post=7294"}],"version-history":[{"count":2,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/posts\/7294\/revisions"}],"predecessor-version":[{"id":7304,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/posts\/7294\/revisions\/7304"}],"wp:attachment":[{"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/media?parent=7294"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/categories?post=7294"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sfj-pharma.com\/wp-json\/wp\/v2\/tags?post=7294"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}